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In The Incredible Hulk, Mr. Blue became infected with Hulk's blood just after Abomination was created. Also, Mr. Blue's head started to show some kind of mutation. What happened to him?

What troubles me: What was the point of showing the infection and mutation? Has he became something notable which Marvel Cinematic Universe has yet to show? Anything from comics?

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The character referred to in the Incredible Hulk film as 'Mr Blue' (e.g. Dr. Samuel Sterns) is referred to elsewhere in the Marvel Comic canon as "The Leader", a super-intelligent megalomaniac with an

'oversized brain housed in a towering cranium, often portrayed as the Hulk's nemesis'

enter image description here

Focusing on the film canon, a recent interview with 'Incredible Hulk' Producer Gale Anne Hurd has indicated that the decision to include a scene in which Professor Stern's forehead is infected with Banner's blood was a deliberate decision to pay homage to the Marvel villain (to which she owns the rights). She goes on to say that she is hopeful that the original character actor, Tim Blake Nelson will return to play The Leader in the upcoming Hulk 2 sequel;

“The Leader,” she said when asked what Nelson was transforming into when last we saw him. “It would be a blast [to put The Leader in the sequel], and Tim Blake Nelson is tremendous and a very talented filmmaker in his own right.”

“When I think of all the many, many, many villains in the Hulk universe, we’ve now done the Abomination, so wouldn’t it be great to tackle the Leader?” she beamed. “It’s a completely different type of cerebral villain, which would give the movie a terrific new take on the character.”

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Getting Tim Blake Nelson to come back to play The Leader in Hulk 2 just got a bit more murky as it was just announced two weeks ago that he's going to play Moleman (or the pre-change version of him) in that new Fantastic Four reboot. –  krillgar May 25 at 20:57
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@krillgar - That's not really a barrier. Don't forget that Affleck (Daredevil) is fronting the new Batman film and Chris Evans (Johnny Storm) is fronting the new Captain America films. –  Richard May 25 at 21:35
    
I do agree with that point. I think it all depends on when Hulk 2 comes out. If they come out close to each other, schedules might conflict. My trepidation is just that it's not a straight ahead as without him being in another movie. –  krillgar May 25 at 22:24

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