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Pinky and the Brain are mice in a scientific laboratory of some sort.

What, if any experiments are being performed on them?

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They took the brain from pinky and put it in the brain. – CandiedMango Jul 10 '14 at 8:40
Same thing we research every night, Pinky. How to take ... – dmckee Jul 10 '14 at 13:45
+1 just for asking about Pinky and the Brain – Shantnu Tiwari Jul 10 '14 at 14:48
Their twilight campaign is easy to explain... – Ben Miller Jul 10 '14 at 16:24
up vote 45 down vote accepted

Some form of genetic experimentation, involving gene splicing, but I'm not aware of anything more specific than that.

They're Pinky and The Brain
Yes, Pinky and The Brain
One is a genius
The other's insane
They're laboratory mice
Their genes have been spliced

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@Roger not necessarily. there's a fan theory out there that says it's actually the reverse: Pinky is the smart one that knows how to do stuff and the Brain is a failed experiment with delusions of grandeur. There's an episode where Pinky writes a formula, Brain corrects it, but it's his version that fails instead of Pinky's. there's also a minor implication due to the order of their names and assigned qualities in the intro. – Nzall Jul 10 '14 at 14:11
@NateKerkhofs Don't forget that One is a Genius, and the other is insance. Brain is clearly the insane one - he consistently tries to take over the world. Pinky keeps stopping him - the genius. – Dr R Dizzle Jul 10 '14 at 14:14
I would just like to thank you fellows in the comments for warping my understanding of a childhood program for the rest of my life :) – Mac Cooper Jul 10 '14 at 16:44
I wouldn't say it's just a fan theory - Season 3 pretty much said as much. See the S3 episodes "Pinky's Plan", "Pinky's Turn" and "The Pinky P.O.V" for evidence. – Omegacron Jul 10 '14 at 17:20
One of the producers said in an interview that Pinky is the genius. If I could just find it, I'd show you. I'd show you all. – James Sheridan Jul 11 '14 at 6:00

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