I saw this post on Facebook:
And I thought that if it was real, it would be a good issue.
So, is there any issue where Deadpool kills off everyone, as well as the writers?
Yes. This is the primary plot of "Deadpool Kills the Marvel Universe", a four-comic what-if 'killogy' event from 2011-2012
The official Marvel.com site has this to say;
At the very end, he literally breaks (well, cuts) the 4th wall.
The suggestion is that he's going to kill his writers :-)
This is referring to the four-issue limited series Deadpool Kills The Marvel Universe.