To the extent that "muggle" means "person unable to perform magic", then yes. These would be Squibs, and J.K. Rowling's old website1 says (emphasis mine):
A Squib is almost the opposite of a Muggle-born wizard: he or she is a non-magical person born to at least one magical parent.
Presumably, then, there are squibs born with two magical parents; alexwlchan's excellent answeralexwlchan's excellent answer provides a list of known examples.
1 Courtesy of the Wayback Machine