The reason is never explained directly in the episode,episode; however, there are a couple of pertinent pieces of information given:
theThe space plane the astronauts are testing is said to have disappeared from radar for a short period during it'sits flight
theThe space plane crashed in the desert, and the astronauts were rescued from the wreck
The episode leaves the viewer to guess what might have happened to the astronauts to cause them to slowly disappear - did the spaceplane cross into some other dimension during it'sits absence from radar, and now they are gradually being drawn back across? Was there an encounter with aliens or a some natural force which is causing them to fade away from reality? Did they all die in space, or in the crash and death is coming to claim them?
Rod Serling, who wrote the screen playscreenplay based on an existing short story, later commented on this episode:
“When Dick Matheson first wrote the story, it had nothing to do with astronauts. At least if I’m dealing with outer space, I can say something, someone [caused the disappearances], and I’ve got a little bit more going on.”
So the his intent seems to have been to leave the cause deliberately vague whilst focusing on the ever increasing desperation and confusion of the unfortunate protagonist.