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No limitations have been mentioned for hybrids. There are some cannon cases of hybrids having offspring:

In The Drumhead, crewman Simon Tarses is put on trial and suspected of having falsified his origins as 1/4 Vulcan, when he is in fact 1/4 Romulan (to which he pleads the fifth seventh). Since we know that Romulans are an offshoot species of Vulcans, odds are that their genetics are relatively similar for reproduction.

Crewman Daniels was also of multiple origins, one of which was Vulcan, suggesting that interbreeding is quite extended by the 31st century.

In the non-cannon part, a few lines were dropped from Star Trek IV where it would have been revealed that on the Genesis planet (in III), Saavik had had sex with Spock (since he was going through a few instances of pon farr thanks to the accelerated aging), and later took a maternity leave.

No limitations have been mentioned for hybrids. There are some canon cases of hybrids having offspring:

In The Drumhead, crewman Simon Tarses is put on trial and suspected of having falsified his origins as 1/4 Vulcan, when he is in fact 1/4 Romulan (to which he pleads the fifth seventh). Since we know that Romulans are an offshoot species of Vulcans, odds are that their genetics are relatively similar for reproduction.

Crewman Daniels was also of multiple origins, one of which was Vulcan, suggesting that interbreeding is quite extended by the 31st century.

In the non-canon part, a few lines were dropped from Star Trek IV where it would have been revealed that on the Genesis planet (in III), Saavik had had sex with Spock (since he was going through a few instances of pon farr thanks to the accelerated aging), and later took a maternity leave.

No limitations have been mentioned for hybrids. There are some cannon cases of hybrids having offspring:

In The Drumhead, crewman Simon Tarses is put on trial and suspected of having falsified his origins as 1/4 Vulcan, when he is in fact 1/4 Romulan (to which he pleads the fifth seventh).

Crewman Daniels was also of multiple origins, one of which was Vulcan, suggesting that interbreeding is quite extended by the 31st century.

In the non-cannon part, a few lines were dropped from Star Trek IV where it would have been revealed that on the Genesis planet (in III), Saavik had had sex with Spock (since he was going through a few instances of pon farr thanks to the accelerated aging), and later took a maternity leave.

No limitations have been mentioned for hybrids. There are some cannon cases of hybrids having offspring:

In The Drumhead, crewman Simon Tarses is put on trial and suspected of having falsified his origins as 1/4 Vulcan, when he is in fact 1/4 Romulan (to which he pleads the fifth seventh). Since we know that Romulans are an offshoot species of Vulcans, odds are that their genetics are relatively similar for reproduction.

Crewman Daniels was also of multiple origins, one of which was Vulcan, suggesting that interbreeding is quite extended by the 31st century.

In the non-cannon part, a few lines were dropped from Star Trek IV where it would have been revealed that on the Genesis planet (in III), Saavik had had sex with Spock (since he was going through a few instances of pon farr thanks to the accelerated aging), and later took a maternity leave.

No limitations have been mentioned for hybrids. There are some cannon cases of hybrids having offspring:

In The Drumhead, crewman Simon Tarses is put on trial and suspected of having falsified his origins as 1/4 Vulcan, when he is in fact 1/4 Romulan (to which he pleads the fifth seventh).

Crewman Daniels was also of multiple origins, one of which was Vulcan, suggesting that interbreeding is quite extended by the 31st century.

No limitations have been mentioned for hybrids. There are some cannon cases of hybrids having offspring:

In The Drumhead, crewman Simon Tarses is put on trial and suspected of having falsified his origins as 1/4 Vulcan, when he is in fact 1/4 Romulan (to which he pleads the fifth seventh).

Crewman Daniels was also of multiple origins, one of which was Vulcan, suggesting that interbreeding is quite extended by the 31st century.

In the non-cannon part, a few lines were dropped from Star Trek IV where it would have been revealed that on the Genesis planet (in III), Saavik had had sex with Spock (since he was going through a few instances of pon farr thanks to the accelerated aging), and later took a maternity leave.