I believe this might be the movie Wolf with Jack Nicholson, Michelle Pfeiffer & James Spader.
Male lead gets wounded by a wolf on the night of a full moon, and he doesn't pay much attention to the wound. After this the male lead's sense of smell is enhanced a lot.
Nicholsons character is bitten by a wolf his car strikes while driving at night in Vermont.
The male lead once handcuffed himself in the bed at night, to constrain himself from turning into a werewolf and hurting someone.
He cuffs himself to a radiator.
Around the end of the movie, the male lead fights with another werewolf to protect the female lead. The female lead is rescued and the male lead turns into a werewolf and runs away. In a conversation with the police, the female lead said her hearing is so sensitive that she knows what is happening a mile away. (This hints she is becoming a werewolf.)
Rather than hear things a long way off, she shows hightened senses by smelling alcohol on the policeman's breath from some distance away.
Laura herself shows heightened senses when the police arrive; telling Bridger that she can smell vodka on his breath before taking her leave
I enjoyed the movie myself, but remember being confused, it's the first movie I saw where the characters were obtusely genre blind - danger TV Tropes link - genre blind