What's the oldest "accidental (potion) ingredient as inciting incident" story?

Is it 1886's The Strange Case of Dr. Jekyll and Mr. Hyde, where the accidental ingredient a "impurity of [unknown] salt"?

The TVTropes entry for this event seems to be a possible variant of what they call Accidental Discovery, Freak Lab Accident, or Miraculous Malfunction.

What's the oldest "accidental (potion) ingredient as inciting incident" story?

Is it 1886's The Strange Case of Dr. Jekyll and Mr. Hyde, where the accidental ingredient's a "impurity of [unknown] salt"?

The TVTropes entry for this event seems to be a possible variant of what they call Accidental Discovery, Freak Lab Accident, or Miraculous Malfunction.

What's the oldest "accidental (potion) ingredient as inciting incident" story?

Is it 1886's The Strange Case of Dr. Jekyll and Mr. Hyde, where the accidental ingredient is a "impurity of [unknown] salt", apparently?

The TVTropes entry for this event seems to be a possible variant of what they call Accidental Discovery, Freak Lab Accident, or Miraculous Malfunction.

What's the oldest "accidental (potion) ingredient as inciting incident" story?

Is it 1886's The Strange Case of Dr. Jekyll and Mr. Hyde, where the accidental ingredient a "impurity of [unknown] salt"?

The TVTropes entry for this event seems to be a possible variant of what they call Accidental Discovery, Freak Lab Accident, or Miraculous Malfunction.