The University of Minnesota scenes are meant to take place in either the Minneapolis or Saint Paul campus.
In episode 1x06, there's a shot of a sign that says "College of Biological Sciences". Only the Twin Cities branch of the University of Minnesota has a College of Biological Sciences specifically named like that. CBS has buildings on both the Minneapolis and Saint Paul campuses; I was unable to identify any of the buildings seen in the show.
The sign also says "Molecular, Cellular, Developmental Biology and Genetics". The U of M does have a Molecular, Cellular, Developmental Biology and Genetics program, but the buildings it's housed in don't really look like what we see in the show: Molecular and Cellular Biology and Jackson Hall
It's possible they faked the building signs and shot them in Toronto like most of the series. If so, they did a pretty good job of matching the U of M's sign style.
I doublechecked the episode and took a screenshot of the aforementioned exterior shot: