That page is from Deadpool kills the Marvel Universe. Where Deadpool is... well, you get the idea. And Deadpool being Deadpool, he's referring to something beyond the fourth wall: Wolverine's popularity as a Marvel character. Cropped out the gorier bits but sticking it behind a spoiler anyways in case you don't like blood (spoiler alert: he kills Wolverine). Typed up his speech below, sans bloody end.
But see... I killed you once... and I bet you'll come back again... no matter how many times I slaughter you. Your tendency to come back from the brink of death has nothing to do with your healing factor. Your mutant power isn't regeneration. It's popularity. But don't worry. I've got big plans... and all the popularity in the world can't save you this time!