Screenwriter and Director Don Mancini states that while Glen/Glenda resembles David Bowie/Ziggy Stardust, there is no intentional reference.
A CampBlood exclusive interview with Don Mancini:
Was the Glen doll in Seed modeled after Mia Farrow? Seriously...
Glen has also been compared to David Bowie/Ziggy Stardust, as well as
to Lucille Ball. I was going for a Tim Burton or Edward Gorey sort of
look -- monstrous yet innocent. I suppose that description could apply
to all of the above -- but I have my doubts about Mia Farrow's
In a separate interview with NYMag, Don Mancini states that he wanted to make Glen gay. He also states that the only point of reference used is the Ed Wood film Glen and Glenda:
You’ve said that Universal passed on the script for Seed of Chucky
because they felt it was “too gay.”
Well, people have expectations for the fifth movie in a slasher
What did they expect?
Son of Chucky, another killer doll. I thought it’s much more
interesting if the child is completely sweet and innocent and wants
nothing to do with that activity. The bottom line is, “What if Chucky
had a gay kid?” To me, that’s hilarious.
Do you reference other coming-out tales?
No. Only Glen or Glenda, the Ed Wood film. I wanted this one to be
more like Ordinary People, very character- and dialogue-driven.