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One of the PowerPuff girls biggest rivals/foes were the Rowdyruff Boys. The Rowdyruff Boys appear to have the same powers and strengths that the Powerpuff girls. So what was the origin of the Rowdyruff Boys?

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According to the Rowdyruff Boys page on the Powerpuff Girls Wiki, the Rowdyruff Boys (Brick, Boomer and Butch) were created by MoJo JoJo in "The Rowdyruff Boys" as a response to the Powerpuff Girls.

The initial 'recipe' came from Professor Utonium himself, who saw no problem giving away the secret to the most powerful creations the world had ever seen over the phone, but the more 'manly' replacement for Sugar, Spice, and Everything Nice was Snips, Snails, and Puppy Dog Tails. These ingredients were taken from the Nursery rhyme "What are little boys made of?".

The replacement for Chemical X, which MoJo JoJo lacked in prison, was black slime found on a prison toilet.

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    "black slime found on a prison toilet" ... hmm, glad I'm not having lunch right now! – Rand al'Thor Nov 29 '15 at 13:47

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