Is there any relation between a Dire Wolf and a D-Wolf?
D-wolves – Guardians of the Sareer on Arrakis in the time of Leto II Atreides; ferocious wolves descended from Gaze Hounds and ordinary wolves, "noted for their keen eyesight."
From their description
... largest dire wolves would have been considerably larger than any modern gray wolf. The dire wolf is calculated to have weighed 25% more than living gray wolves.