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Jared Padalecki portrayed Dean in Gilmore Girls and then, in Supernatural, his chararacter Sam had a brother named Dean.

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Jared Padalecki's roles in Gilmore Girls and Supernatural are among his most well known:

[He] rose to fame in the early 2000s after appearing [as Dean Forester] on the television series Gilmore Girls [...]. Padalecki is best known for his role as Sam Winchester on Supernatural.

from Wikipedia

Has anyone involved in making Supernatural ever mentioned whether Sam's brother being named Dean was a reference to Gilmore Girls?

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No.

Eric Kripke, the creator and original showrunner of Supernatural, named Dean (and more indirectly Sam) as a homage to Jack Kerouac's road-trip novel On the Road.

From an article on DailyTelegraph:

At the heart of the show are brothers Sam and Dean Winchester (Jared Padalecki and Jensen Ackles). When they were young their mother was killed by a demon. Now they're on a quest to hunt down such ghouls.

The brothers were named after the characters Sal and Dean, from the classic beat novel On The Road, by Jack Kerouac. Kripke didn't like the idea of having a lead named Sal, so he switched to Sam.

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