Why a worthy hunt? Individuality.
This echos in the famous lines at the end of the first movie:
Dutch: "What the hell are you."
The Predator: "Whaat, th' 'ell, ar' 'oou."
Weapons mean nothing in the end. Only those with unique minds--independent of their species instincts--make weapons useful.
See MacGyver and what ingenious things he creates from mundane materials. MacGyver would be a Hunter's ultimate choice.
Furthing that point: The Predator removed his weaponry before Dutch, because he clearly wanted a challenge. Not by removing his weapon, but by leveling himself to Dutch's level, so their individual minds now become the weapons. And Dutch does not disappoint; with all the various traps he set, that also bested The Predator in the very end.
This relates to the short story The Most Dangerous Game. And why this game is so dangerous.
Also, Predators takes the iconic lines from the first movie as blueprints when creating the Human characters for the hunting reserve's best stock.
Most of the action in that movie relied on each character's unique mindset, forged over their lifetime. Some of the Humans' actions went against what some of the Predators assumed would be the outcome; if said Predators only considered Human instinct and not sentient intelligence.
The character "Edwin" points to this. He had no big weapons, seemingly no sort of indication in his dress and demeanor--even sometimes anxious-- that may have suggested a hard past the others endured through war and crime. He was an "average Human stock" upper-blue-collar MD. Some may have wondered why he was picked to be included among all these hardened others.
He was a psychotic serial killer; paralyzing Isabel via neurotoxin and suggesting this as offering to the Super Predator. All executed by pure cunning. The physical weapon? A pocketed scalpel; as weapon of choice in his past murders. He slices Isabel with it and delivers the neurotoxin as intended.