Chernobyl is the ur-example of a real Blighted Land. There is an 18 mile exclusion zone around the melted reactor that is deemed not fit for human habitation (this is of course ignored by animals, which appear to be thriving, but that is another point). I can think of two examples of fiction off the top of my head where human meddling has absolutely destroyed a locale, and both were written after Chernobyl. I'm curious if, in much the same way that death was first personified during the European plague, the concept of a blighted/destroyed land has been crystallized and given a form and appearance by the public awareness of Chernobyl.
Star Trek Voyager: In "The Omega Directive" it is revealed that a Federation scientist is working with the "omega molecule" which destroys subspace in a large area, making it impossible to use a warp drive in this area, effectively keeping all planets inside in a slower-than-light state for eternity
Dominic Deegan: In the Orc wars the kingdom of Callan employed "Informancers" which where humans bound to demons. The effect of so many demonic entities concentrated in one place eventually led to a condition in which the Orc plains were blasted by sandstorms for months, destroying all civilization, and forcing the Orcs to become nomads at best, and refugees at worst.
While the cause of the blight could be variable, I'm looking for in general the Irradiated level of blight - e.g., there is nothing we can do about it for millennia (or ever), we just have to wait it out.