According to the Marvel wiki on adamantium ,
A sufficient amount is capable of surviving multiple nuclear explosions with no damage.
And an answer on another question here says that Wolverine can regenerate with only his skeleton left (the other, IIUC, says he doesn't even need his whole skeleton).
So, does wolverine have enough adamantium arranged in such a way that he could survive even a nuclear strike? And if even "nuke it from orbit, it's the only way to be sure" doesn't work, can he be killed?