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In the movie a man is killed and his brain was connected to a large spacecraft. His memory was wiped. His wife is searching for him, and toward the end he remembers who he is and what happened to him at the same time his wife finds out.

It ends with him deciding to go off into deep space to explore, I think he took some old scientist with him, but I am not to sure about that. I remember only seeing the last half of the movie.

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From the timeframe, it could be Lifepod(1981).

The plot summary, from Wikipedia:

The film takes place in 2191. The latest space liner for the Whitestar Lines is the Arcturus, currently on its maiden voyage. On its approach to Callisto, for unknown reasons, the ship's computer, the Main Cerebral, declares a red five emergency, and orders "abandon ship". Most of the crew and passengers leave in lifepods. Captain Montaine (Christopher Cary) stays on the bridge. Cerebral begins to evacuate the ship's compartments of oxygen. Third astrogator G.W. Simmons is caught on deck 16 while it still retains an atmosphere. He runs into Fiona Harrison (Kristine DeBell) a passenger from deck 15 who did not leave with the others because she had to go back for her bird, Dwayne. Because life support has been shut down for all the decks below, Simmons and Fiona head to the bridge via an elevator. When the doors open on deck one they are met by news reporter Roz Keshah (Carl Lumbly) from level 3, he is wearing a tiny and discrete, optical head-mounted display/camera predictive of Google Glass. He has found two people, Whitestar Lines director and major stockholder Lloyd DeMatte and his companion the Lady Lima.

On the biobridge the five meet Captain Montaine, who is accosted by DeMatte and accused of damaging the Arcturus. The captain explains the situation, then offers an escape tunnel to a lifepod. He remains behind, out of duty as the captain and also a strong sense of curiosity. Fiona accidentally leaves Dwayne behind, who becomes a sort of companion for the captain.

Simmons takes command of lifepod#3; DeMatte attempts to hijack it and is killed in the process. It is revealed that the Arcturus was intended as an interstellar vessel but repurposed for economic reasons by financial-criminal DeMatte, The Main Cerebral is discovered to be the former intended pilot of the interstellar Arcturus, rendered an amnesiac and made cyber-controller of the interplanetary Arcturus by DeMatte; memory restored, he launches the Arcturus on a flight to Sirius, accompanied by Captain Montaine.

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