In Deadpool the movie we see him cut his hand off,
And we know that Deadpool has regenerating powers an that he can even regenerate from a single living cell, so what happens to the hand that colossus has?
What happens to his hand?
In the comics his severed parts are collected by an avid fan. When there's sufficient of them, they grow into a new Deadpool, but one that's evil...
Well, if you keep it more practical, then, you know, deadpool needs mass & energy to regenerate his organs. But for the detached limbs and other things, that mass & energy - which in case of deadpool's main body, comes from the foods he been eating or stored in body - isn't enough to regenerate a whole new body. But if his detached parts get evolved and if cells can absorb the energy&mass required, acting as single metabolisms or alike, then i think it is not impossible to regenerate a whole new & bulky body to entertain us :D