MJ typically appears with striking red hair
Has she ever had an noticeable changes to her appearance in the last 50-ish years?
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Hitomi Sakuma is Supaidāman's version of Mary Jane.
Mary Jane was portrayed by several actresses in this musical, one of whom, Rebecca Faulkenberry, had brown hair.
There's also a universe where Mary Jane is an anthropomorphic water buffalo, but she retains her red hair.
By mistake in Daredevil #77 (Source)
Mary Jane Watson with blonde hair (and Peter Parker with black hair).
And yes, this issue of Daredevil was published BEFORE Gwen Stacy died. (This issue is cover dated as June 1971. Gwen died two years later in Amazing Spider-Man #121, cover dated June 1973.)
Other than that, the red hair has been a defining characteristic (although it has changed styles many times)....even in other Marvel universes....and when she's been completely transformed into, say, the Demogoblin [Earth-1610]
Well, on Himarm's advice, I am turning my comment as an answer:
In Ultimate Spider-Man vs the Sinister 6 - S4E15 named Symbiote Saga: Part 3, Mary Jane Watson was transformed into Carnage Queen.
Below are the pics on how MJ turned to Carnage Queen:
Also, below is the pic where a mutated Morbius tried to control Carnage Queen by putting a yellow-colored mind-control device on her head: