Short Answer: The issue she debuts against the Avengers in Avengers Annual #10 has her using her mutant powers against nonmutants quite effectively, disabling Captain America and Thor with her powers. At that point she has already gathered the powers of the non-mutant Ms. Marvel as well. She can only gain powers from living beings so Iron Man was safe against her touch as long as he remained in his armor. Sentinels are also proof against her touch.
A more detailed explanation of Rogues' powers
Rogue's powers (like so many mutants) has limits that are undefined and vary significantly from writer to writer. Her original mutant power was the singular ability to absorb the mental and metahuman capacities of other mutants. She has always been able to hold the templates for more than one metahuman at a time without any serious consequence to her. The basic premise is upon touching the uncover skin of another person:
- She renders them unconscious.
- On a one to sixty ratio (1 second = 60 seconds) she is able to access their short term memory. In the cases of longer contacts, she is able to gain deeper memories and has lost her own memories during this time.
- In the case of a metahuman who derives their powers from an internal source (mutant, mutate, and likely Eternal) she is able to replicate their metahuman capabilities with the same level of performance as the original owner.
- Her power has even worked on beings who derive at least part of their power from magical origins, such as Thor.
- At one time Rogue did not possess the ability to prevent the absorption of another's mental or physical powers at this time.
Rogue's powers were transformed when she absorbed the abilities of Ms. Marvel, permanently. The absorption was complete leaving (temporarily) Carol Danvers without any powers at all. The absorption of Ms. Marvel's powers has had controversy since Rogue has significantly greater powers than Ms. Marvel had displayed until that point.
Since Ms. Marvels powers were derived from Kree technology, it is possible there was an unexpected interaction allowing Rogue even greater power than Ms. Marvel displayed.
Rogue has superhuman strength, resistance to injury, flight, heightened reflexes and a "seventh sense" making her capable of holding her own against mutants as powerful as Colossus, Mr. Sinister, Apocalypse, and other metahumans such as Iron Man and the Avengers.
Currently Rogue has been transformed by a variety of writers and storylines that allowed her power to be reset and developed normally.
She can now use her powers and they are under her complete control.
- She does not have to absorb the mental or physical powers unless she wants to.
- She can even kill a person if she does decide to hold on until their mind is a blank slate.
- She can use her powers to replicate the abilities of any person whose powers she has replicated in the past. Her default state still seems to resemble her powers she gained from Ms. Marvel, likely because it was a state she held for such a long time.
- She can still use more than one metahuman template at a time combining their powers and making her, physically, one of the most powerful mutants on Earth.
Rogue's Wikipedia entry shows the number of times her powers have been reset, reconfigured and the stories associated with those changes. Makes for confusing reading, and I have read the actual comics.