This movie was from between 2000-2005
The story starts out with a woman from other planet who hid on Earth. She has very long life and she became the wife of many kings because of her longevity.
She was followed by two aliens (who had destroyed her planet) hence why she had to run.
She has a brother from whom she was separated when coming to Earth. She has her brother's hand and the two aliens give a synthetic hand to her brother.
She has a holy ring which can kill these two alien and the end of the film has her inserting the (blue) holy ring into the alien guy's body.
Because the body is possessed by the two aliens, this causes them to die.
Wesley is an expert on extra-terrestrials from his association with the Aliens Analyzing Agency, an expensive, but secret, arm of the UN. He meets Fong at an antique shop in San Francisco viewing a curio. It's a skeletal hand made from glowing blue crystal. Fong must have it because of its sentimental value. It was her brother's.
Naturally, Wesley falls for Fong. Fong is from Dark Blue. She is the sole surviving Blue Blood alien having fled her planet when it was infested by the Warlock Toxin Gang. She and her brother, Tan, came to Earth 600 years ago after the lost Blue Blood Bible they need to battle the Warlock Toxin Gang. The Warlock Toxin Gang appear to be worms with a hive mind forming a nasty gestalt; a gestalt that can change its appearance to match anyone it consumes.
Here's a subtitled trailer: