We don't know
Very little of the Doctor's life (before the show began) has been explored on the show, and we know nothing about his family except that they existed. It's certainly possible that Susan is related to either River or Jenny, but it's never been explicitly confirmed nor explicitly denied by anything we've seen1.
If you widen your scope to the Doctor Who expanded universe, then we still don't know but it does become more unlikely; at least two works propose mutually incompatible theories for Susan's origin, both casting doubt on your theories:
- The short story "Birth of a Renegade" raises the possibility that Susan isn't actually biologically related to the Doctor at all, instead casting her as a colleague who stowed away on the TARDIS stolen by the Doctor
- The novel Lungbarrow proposes that Susan is the biological granddaughter of "The Other", a figure from Gallifrey's mythic past and contemporary of Rassilon and Omega. The Doctor is supposed, in this story, to be a kind of genetic reincarnation of the Other, making him Susan's grandfather only technically
All that being said, feel free to invent a new backstory for Susan for your roleplaying; it won't be any less canon than anything else we know about her, and Doctor Who has a proud tradition of retconning in any case.
1 Personally I find both to be unlikely, because it seems odd for the Doctor to not recognize the mother of his children or grandchild (and he clearly doesn't recognize either River or Jenny in their respective debut episodes). Time travel being what it is, of course, this isn't a terribly strong argument against either theory, which is why it gets a footnote