I've been wracking my mind to track down a book I read in 1981 or so. What I remember: It was set in the nearish future and genetic engineering was common. Some people had super or even godlike powers. At least one lived in a fourth dimension, had worshippers, and manifested as a giant hand reaching from a hole in space (?). I think at least one character was a woman with super strength, though I may be conflating her with a similar character from Zelazny's Creatures of Light and Darkness.