Isobel Ross, wife of Robert McGonagall, lived as a Muggle.
Isobel Ross fell in love with and married a Muggle minister. She became a housewife, and lived with him, having given up the magical world.
Isobel and Robert moved into a manse (minister’s house) on the outskirts of Caithness, where the beautiful Isobel proved surprisingly adept at making the most of the minister’s tiny salary.
- Professor McGonagall (Pottermore)
She kept her wand in a locked box, and didn’t use magic - for a while she hadn’t even told her husband that she could.
Isobel was torn between pride and fear. She knew that she must confess the truth to Robert before he witnessed something that would alarm him. At last, in response to Robert’s patient questioning, Isobel burst into tears, retrieved her wand from the locked box under her bed and showed him what she was.
- Professor McGonagall (Pottermore)
Even after she revealed that she was a witch, she didn’t seem to return to using magic.
Now estranged from her family, Isobel could not bring herself to mar the bliss of the honeymoon by telling her smitten new husband that she had graduated top of her class in Charms at Hogwarts, nor that she had been Captain of the school Quidditch team. She sensed, too, how much of a strain it was for her mother to fit in with the all-Muggle village, and how much she missed the freedom of being with her kind, and of exercising her considerable talents.
- Professor McGonagall (Pottermore)
It’s unclear exactly how long she had lived as a Muggle, but it seemed to be quite a while - she began before her daughter was both, and seemed to be in the same Muggle village 20 years later, after Minerva had turned eighteen and spent two years working at the Ministry before becoming a teacher at Hogwarts.
Nevertheless, it was a shock to learn from the oblivious Isobel (in the middle of a chatty letter of local news) that Dougal had married the daughter of another farmer.
- Professor McGonagall (Pottermore)
It’s never mentioned if she ever went back to using magic, but she spent more than 20 years in that Muggle village, where she was “unable to exercise her considerable talents”.