Consider this : Padmé Amidala became queen when she was only 14. She served two terms and then promptly became Senator. The book "Darth Plagueis" mentions that Palpatine specifically lobbied on her behalf during Naboo monarch elections. Padmé had little formal education (Legislative Youth Program, some kind of political school), no real life experience and never had to work a day in her entire life, much like many politicians today belonged to a political class with little contact with ordinary people. In movies and novelizations she was described as idealistic, passionate for democracy, brave but IMHO not very bright.
In Senate, she was one of the leaders of opposition to Chancellor Palpatine, along with Prince Bail Organa, Mon Mothma and some other Senators, the Senators mentioned also being from privileged families. Could it be that Palpatine actually wanted and created such opposition ? Neither of the Senators (especially Padmé) had much practical knowledge on how the Galactic economy works, they didn't have military experience, they didn't have technological knowledge, they didn't have a clue about problems of ordinary people. All they had were lofty political ideals and their careers as political hacks. Neither of them (again especially Padmé) could effectively gather enough support, both in population and in Senate, to challenge Palpatine. Yet, they were successful in blocking some other, maybe more talented and effective people, from leading opposition against Palpatine.
Also, Palpatine was one of very few people that knew about the secret relationship and latter marriage between Anakin and Padmé. He actually played the role of matchmaker and pushed them together when he, specifically, set Anakin as her bodyguard. With Anakin being his greatest prize, and Padmé being Anakin's greatest secret and weakness, is it possible that he (Palpatine) again just used her to effectively sway one of most powerful Jedi to his (Dark) side ?
And finally, when her usefulness was exhausted, did Palpatine simply get rid of her? (Whether Palpatine killed Padmé is whole another question, I will not dwell on that here.) But could it be that for her entire life, Padmé Amidala was just the unwitting pawn of Palpatine, used for his nefarious aims, and when he no longer needed her, he just discarded her like so many others ?