This question already has an answer here:
In Jurassic Park, we're told that the dinosaurs are built with a failsafe.
ARNOLD: The lysine contingency is intended to prevent the spread of the animals is case they ever got off the island. Dr. Wu inserted a gene that makes a single faulty enzyme in protein metabolism. The animals can't manufacture the amino acid lysine. Unless they're continually supplied with lysine by us, they slip into a coma and die.
Which is all fine and good-- unless you then make three sequels filled with dinosaurs, none of which are being provided lysine. The first two sequels take place on an island that's been completely abandoned by In-Gen. Jurassic World features the original T-Rex, even though it should have died after the first Jurassic Park was abandoned.
Did they ever address this address this in the sequels?