In the Framework, Daisy and Simmons (at least) had avatars whose places they took: people with their own personalities and backstories, quite different from their outside counterparts. At first it seemed that Ophelia was different, simply being the name that Aida used while in the Framework. However, after Daisy injures her, Aida exits the Framework. After this, we see Ophelia talking to Fitz, urging him to complete Project Looking-Glass.
Does Aida have a presence inside the simulation even when not connected? Does Ophelia have her own avatar, and, if so, is she the same as Aida, or does she believe herself to be Madam Hydra?