The Desolation of Smaug does not mean the Destruction of Smaug.
Definition of desolation
- the action of desolating
the pitiful desolation and slaughter of World War I — D. F. Fleming
- grief, sadness
... he put his trembling hands to his head, and gave a wild ringing scream, the cry of desolation. — George Eliot
- devastation, ruin
a scene of utter desolation
- barren wasteland
looked out across the desolation
desolation — Merriam Webster
So while The Desolation of Smaug could be construed as Smaug being laid to waste, a more likely explanation if we take the first meaning of desolation as given above, that it's Smaug laying the land around him to waste.
But far more likely are the other three meanings of the word; the sadness or loneliness of Smaug, the grief or devastation caused by Smaug, or the barren wasteland around Smaug's lair in the mountain Erebor.
Now let's turn to the book.
The land about them grew bleak and barren, though once, as Thorin told them, it had been green and fair. There was little grass, and before long there was neither bush nor tree, and only broken and blackened stumps to speak of ones long vanished. They were come to the Desolation of the Dragon, and they were come at the waning of the year.
The Hobbit, "On the Doorstep"
This quote, along with the map, clearly shows that it's the fourth meaning that's used here, the barren wasteland around Erebor, which is what the party had just reached in the quote.
Of course, as is the beauty of any language in words can have several, related meanings, all these meanings are invoked when used in the film's title like this. But it is clear that it does not have to mean Smaug being laid to waste.