I was wondering if only the Kwisatz Haderach could interact with sand trout and become a human-worm hybrid or could anyone do it? I don't remember the process that Leto had to go through to become a hybrid very well.
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5At minimum you need a massive tolerance to the Water of Life.– OrangeDogNov 24, 2017 at 12:16
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No. Only someone with prescience, the experience of past lives, and total control over their metabolism could have become a worm-human hybrid.
No sandtrout had ever before encountered a hand such as this one, every cell supersaturated with spice. No other human had ever before lived and reasoned in such a condition. Delicately Leto adjusted his enzyme balance, drawing on the illuminated sureness he'd gained in spice trance. The knowledge from those uncounted lifetimes which blended themselves within him provided the certainty through which he chose the precise adjustments, slaving off the death from an overdose which would engulf him if he relaxed his watchfulness for only a heartbeat. And at the same time he blended himself with the sandtrout, feeding on it, feeding it, learning it. His trance vision provided the template and he followed it precisely. (Children of Dune)
For normal people, the sandtrout-glove would simply slip off after a while:
For a moment, though, he'd felt the reality of his terrible decision. The sandtrout glove. It was the play of children. If one held a sandtrout in the hand, smoothing it over your skin, it formed a living glove. Traces of blood in the skin's capillaries could be sensed by the creatures, but something mingled with the blood's water repelled them. Sooner or later, the glove would slip off into the sand, there to be lifted into a spice-fiber basket. The spice soothed them until they were dumped into the deathstill. (Children of Dune)
answered Nov 24, 2017 at 12:17
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Leto II told Siona that she could do it because she was an Atreides, indicating that a certain peculiarity of their genetics was required as well. Dec 15, 2017 at 16:31
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@Omegacron, absolutely true. Also, Paul Atreides could have done it as well. Leto in his journals: I began this account in the first year of my stewardship, in the first throes of my metamorphosis when I was still mostly human, even visibly so. The sandtrout skin which I accepted (and my father refused) which gave me greatly amplified strength plus virtual immunity from conventional attack and aging-that skin still covered a form recognizably human: two legs, two arms, a human face framed in the scrolled folds of the sandtrout. Jan 25, 2018 at 19:26