I've seen some people claiming (and some repeating it) that Gene Roddenberry intended TOS to be excluded from Star Trek canon after making the first episodes of TNG.
I failed to find any evidence regarding The Original Series, supporting this claim. I think, in order to make a statement of such magnitude, there should be some quotes that clearly support this attitude.
I mean, it does make sense if we think about how much he hated making TOS compatible for the masses, but I always thought he managed to slip in his messages pretty well, while still disguising it as the western show he was supposed to deliver. So, announcing it was non-canon would also contradict the effort they took up to preserve continuity when creating TNG.