During the events of the first Dead Space game, the Red Marker is transported from the cargo deck of the USG Ishimura to the planet below: Aegis VII. This is where (Altman's) Red Marker was originally found by the mining ship.
However, both Terrence Kyne and Isaac Clarke are under substantial influence by the marker, and both are convinced and assisted by the marker's hallucinations (Amelia Kyne and Nicole Brennan, respectively) to return it to the planet.
Only after Isaac somehow breaks free from the marker's influence on the surface (partly due to Kendra Daniels influence, the only one who appears unaffected by the marker), can he destroy the marker.
If the marker's goal is to spread, it should remain on the Ishimura, where it is most likely that more vessels arrive to investigate, and where the marker has a shot at getting to a place with more organism (e.g. Earth). The marker has a veritable army on the Ishimura. But clearly it is trying very hard to get to Aegis VII, by manipulating Kyne and Isaac. Why?