In the Blade movie series, vampires turn into ashes when killed (or scratched?) by silver.
In the first movie, Blade was in that vampire nightclub hunting Deacon Frost's friend, Quinn, who got impaled twice by silver yet didn't turn into ashes. Do you need to aim for the heart / brain?
In other scenes some vampire goons turn into ashes when simply being hit (arms, legs) by Blade's silver sword.