Is Marvel going to make another movie that follows what happens after Spider-Man: Homecoming.
Most likely, but not necessarily "Homecoming 2"
Tom Holland himself has confirmed that he is contracted to three solo films and three "other" films (likely joint films with Avengers, etc):
They give you options and those could be exercised whenever. Like a cameo in Avengers," Holland says of Marvel. "I'm unclear as to which movies though. I do know I have three Spider-Man [appearances in other] movies and three solo movies contracted...
'Spider-Man': Tom Holland Reveals How Many Marvel Films He's Signed For - The Hollywood Reporter
While this may not specifically be titled "Homecoming 2" we can expect at least 2 more Spider-Man sequel films, starring Tom Holland, as well as at least two more films (as of the date of writing) featuring Spider-Man amongst other title characters.
Kevin Feige, Marvel Studios President, had stated (before the release of the Homecoming) that if they were to make sequels, taking on an approach to the Harry Potter stories was something they had in mind from early on.
Should we be able to make more after that? Sure. This is sophomore year, is the next one junior year? Is the next one senior year? Is there a summer break between each of those? I don’t know what, but it was sort of how do we do a journey for Peter not dissimilar for what the students of Hogwarts would go through each of their years, which was one of the early ideas we had for the movies.
Kevin Feige Says ‘Spider-Man’ Sequels Could Follow the ‘Harry Potter’ Format - Collider
There is a new trailer out for the Spider-Man: Far from Home film starring Tom Holland, to be released in the summer of 2019. The trailer strongly implies that it builds upon the immediate aftermath of Avengers: Endgame, primarily the
Death of Tony Stark.
It contains an official warning that it contains major spoilers for that movie.