No, not more than other weapons
If you read (and preferably reread, a few times) what Lewis says via Aslan, the emphasis isn't on the deplorable word itself.
The emphasis is on people's beliefs and attitudes. Charn and Jadis are used as a warning of what can happen when a ruler thinks primarily in terms of themselves, rather than in terms of their obligation to society. Nearly the entire discussion is of how Empress Jadis had lost sight of happiness, justice and mercy, and cared only about her own power--and preventing her sister from getting it.
Lewis describes the Deplorable Word as something Jadis' ancestors had known of for many years (generations). I'd see this as specifically disassociating it from a type of weapon that was new in his time. Rather, it's attempting to refer to the "ultimate weapon", regardless of what that may happen to be at a particular time--regardless of whether that happens to be a legion of bronze-age spears, gun-powder, a nuke, or some future anti-matter weapon.
To Lewis, the weapon was almost irrelevant. What mattered was Jadis, and how she felt (or didn't feel) about her people and her world. To her, it was better to destroy the entire world, and everything in it (except herself) than to let her sister rule. She cared only about power, not about her people.
Lewis specifically avoided referring to any particular weapon or type of weapon. To him, the real evil was tyranny, and Jadis' use of the deplorable word was simply the ultimate expression of tyranny.