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In the movie Downsizing humans can be irreversibly shrunk to about 5" tall. There is a scene with full size people lying on medical beds and soon after a scene where people are in their shrunken state. The room and medical beds appear to be as immaculate after shrinking as it was before shrinking.

This would have me believe the mass was lost either as gas or as energy, such as light or heat.

Was there any confirmation of where the lost mass went?

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    Have you seen the fat buckets after liposuction? If not, google image search. You’re welcome. – RoboKaren May 13 '18 at 1:39
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    A good question and I'm unsure why people are voting to close this as off-topic/science-based since the science of the shrinking process is discussed in the film – Valorum May 13 '18 at 8:31
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This isn't dealt with in either the film, nor the film's original script. The process itself is simply (and intentionally) hand-waved in Dr. Asbjørnsen's speech at the start of the film.

DR. ASBJØRNSEN: ... my team and I discovered a process by which all organic material can be reduced at the cellular level by a ratio of approximately 2,744 to one. Such a process converts a man of 1.8 meters to just 12.9 centimeters. A wide array of flora and fauna were subjected to this process and, with the exception of some fish and shellfish, absolutely no side effects were detected. Please lights.

The room dims. A GROUP PORTRAIT of the gathering at the Asbjørnsen home appears on a screen above the stage -- the first image in a PowerPoint presentation.

DR. ASBJØRNSEN (CONT’D): Once the safety of the procedure was confirmed, thirty-six brave volunteers joined my wife Anne-Helene and me as the very first humans to undergo cellular reduction.

A NAKED SUBJECT poses before reduction, arms extended like Da Vinci’s Vitruvian man. Next he shows off his new TINY BODY beside a metric a ruler held by enormous fingers.

DR. ASBJØRNSEN (CONT'D): The exact science behind reduction itself falls outside of our discussion today....

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