I'm trying to identify an audio book I heard many years ago but can't recall the name. The story involves a human settlement on the moon and a science spaceship with biologic tech and nano tech on board.
The ship AI becomes sentient, and then at some point crashes into Earth. The surviving astronaut wakes up centuries later. The ship evolves into some sort of God-like entity flowing out the crater in which it crashed, using its biotech to play with and mutate the creatures around it. The protagonist meets his ex wife, or a clone of her, who is now in a human spider form. He later learns that the all that remains of the human race is the moon colony.