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I saw an anime on Adult Swim, probably between 2002-2005. It might have been the first episode. But the main character has amnesia or had his memory wiped. He was carrying an acoustic guitar and someone on the street says "Do you play?" and he says no and then plays a really intricate riff and the guy replies "Lying is bad karma, man" and it's obvious the main character doesn't know how or why he can play guitar.

Please know that my quotes are probably paraphrasing the real dialogue.

The anime was in Japanese style but the audio was in English. Also, it was not Phineas and Ferb, I'm familiar with that show.

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    Hi there! :) could you take a look at this guide on how to ask a good (anime) story-id question, see if that triggers any more memories you could edit into your question? – Jenayah Aug 8 '18 at 17:58
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    And can you tell us what the fantasy or science fiction aspects of this are? A memory wipe may be sufficient if you're certain that that's the case. – FuzzyBoots Aug 8 '18 at 20:08
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Android Kikaider: The Animation Episode 3 to be exact.

At 10:46 the other guitar player says "You shouldn't lie like that, it's bad karma!"

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    Hi, welcome to SF&F! Nice find! – DavidW Apr 9 at 1:25
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In the Phineas and Ferb science fantasy cartoon TV show, the season 1 episode “Dude, We're Getting the Band Back Together” (linked description on Phineas and Ferb Wikia, WIKIA WARNING), the protagonists convince a three-man rock band Love Händel who had broken up to play music again. They meet the singer guitarist, then the bass player.

The climax of the episode is when they convince the drummer, Swampy, to return. Swampy insists that he has quit playing music because he has lost his sense of rhythm. However, Phineas and Ferb point out the signs, obvious to both them and the viewer, that Swampy is wrong, and he still has a great musical talent and should play the drum again.

This much matches the description in your question well. The conflict is, this is definitely not an animé show, not even animé influenced, but an American style cartoon TV-show. It was also playing on Disney channel, so it's unlikely to have ever appeared on Adult Swim, the channel owned by the competitor Cartoon Network.

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    I've removed the comment that the OP should edit and reconsider what they remember. While you're welcome to posts guesses, there's no need for that commentary, there's sufficient comments which already exists covering such aspects. – Edlothiad Aug 9 '18 at 9:43

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