From Harry Potter and the Philosopher's Stone:
There have been many reports of the Philosopher's Stone over the centuries, but the only Stone currently in existence belongs to Mr. Nicolas Flamel, the noted alchemist and opera lover. Mr. Flamel, who celebrated his six hundred and sixty-fifth birthday last year, enjoys a quiet life in Devon with his wife, Perenelle (six hundred and fifty-eight).
Yet in Fantastic Beasts: The Crimes of Grindelwald, he clearly lives alone.
What happened to his wife?