I saw this when I was young; I believe it's from the 1990s.
It seemed to be post apocalyptic; it definitely wasn't supposed to look modern. There was a virus or disease or something that turned the people rabid. One scene had a cave full of people who had barricaded themselves in to hide from the infected.
The main characters were going to find a guy who had the last of vaccine against it (he's the antagonist). The vaccine was in a powder form; I think it was orange. This is where the lead female makes her appearance.
I can't remember who any of the actors were.