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I remember watching a cartoon on Cartoon Network in the late 90s or early 2000s on Cartoon Network. I think it is a sci-fi/fantasy anime (not too sure, it could just be an American cartoon). I think the protagonist is called Kenshin. I could be wrong, but he unwittingly causes a curse. It also had witches, some tried to protect him, while others tried to get him.

I have tried searching on Google for years now to no avail.

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Although it doesn't seem to have witches nor does it seem to be sci-fi/fantasy, this might be Rurouni Kenshin. Other than that, it matches very well.

The anime aired on Toonami in 2003 (i.e. on Cartoon Network). The main character is Himura Kenshin. The show's wiki says this about his scar:

According to his allies during his days in the Isshi Shishi, this scar was said to have constantly bled and never healed as the mark of a curse for having slain an innocent person.

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