Yes...
...and it is literally the main plot point of Guardians of the Galaxy Vol. 2. Ego, a Celestial, has created off spring with various other species across the galaxy. Star-Lord, aka Peter Quill, is one of those hybrid children.
Ego: Not long after. It was with Meredith that I first experienced love. I called her my river lily. And from that love, Peter... you.
Guardians of the Galaxy Vol. 2
We later find out he's also done it with various other species, he initially shows us this diorama.
Ego: Out of all my labors the most beguiling was attempting to graft my DNA with that of another species. I hoped the result of such a coupling would be enough to power the expansion.
Ego (O.S.): I had Yondu deliver some of them to me. It broke the Ravager code - but I compensated him generously. And, to ease his conscience, I told him I would never hurt them.
Ego: That was true. They never felt a thing. But, one after the other, they failed me. None of them had the Celestial genes. Until you, Peter. Out of all my spawn, only you have carried the connection to the light.
Guardians of the Galaxy Vol. 2

FWIW I believe the circle in this image is down to a fan theory that Mantis is Peter's sister i.e. Ego's daughter but it's the best quality image I could find so you can safely ignore it.
We later see a lot of his children, in a cave of skulls and skeletons.
Gamora: The bodies in the caverns, who are they?!
[...]
Mantis: The bodies are his children.
Guardians of the Galaxy Vol. 2
