In the MCU Iron Man uses JARVIS as his AI assistance but in the comics when was the first time the concept of something like an AI assistance was used for assisting him and controlling the suit? What was the name of that AI assistance?
This answer relates directly to Iron Man as opposed to the wider Marvel 616 Universe (main comics continuity).
What is considered AI maybe debatable, but the first instance of Iron Man using a personal AI assistant, with a name that you could have a conversation with, was H.O.M.E.R. - Heuristically Operative Matrix Emulation Rostrum.
First appeared in Iron Man issue 298 in 1993 according to marvel.fandom.com