Yes.
The term "Prime Universe" is something that is used out of universe to better distinguish between the various timelines and dimensions that we see in Star Trek. For us, it's the "prime universe", because (apart from Star Trek 2009 and later) all the adventures we see on-screen are told from the perspective of that specific universe.
The Mirror Universe was not the Mirror Universe before Discovery
Note that the term "Mirror Universe" has also not been mentioned in-universe prior to Discovery: this nickname was only part of several episode titles, such as "Mirror, Mirror" (TOS), "Through the Looking Glass" (DS9) or "Through a mirror, darkly" (ENT).
In-universe, Discovery recognized the parallel universe as a mirror universe
In Season 1, Episode 10 of Discovery, the Discovery crosses over to the Mirror universe. Initially, they don't know where they are (they find the records on the U.S.S Defiant later in the episode), but they quickly recognize the parallel universe for a mirror image:
BURNHAM: I'm downloading the Klingon raider's logs Images, battle plans, intelligence that we found from the core. And so far, we can conclude that we are indeed in a parallel universe. But one not governed by the Federation, but by a fascistic, human-only organisation known as the Terran Empire. Most places and ships that are found in our universe, like the Cooper, exist here. The same goes for people.
TYLER: You mean, we could literally meet another version of ourselves?
BURNHAM: Theoretically, yes.
TILLY: Wow.
BURNHAM: The Terrans appear to be the antithesis of us, in every way. They're an oppressive, racist, xenophobic culture that dominates all known space, and they're ruled by a faceless emperor.
(Discovery: Despite Yourself)
They (Or at least Burnham) quickly start referring to their counterparts of the other universe as their mirror counterparts:
LORCA: I'm gonna run with Mister Saru's theory in the hope that we don't bump into ourselves and blow our cover. Burnham.
BURNHAM: Modifying our ship's signature to match that of mirror Discovery.
BRYCE: Captain.
LORCA: Hold on, Lieutenant!
BRYCE: They're saying if we don't respond that we should prepare to be fired on.
LORCA: Open a channel. Audio only.
BURNHAM: Belay that. I'm sorry, but you can't take it, sir. I'm examining the crew manifest of mirror Discovery. You're not its Captain.
(Discovery: Despite Yourself)
It makes sense to use the wording "prime universe" in this dialogue
By the time of Season 2, Episode 11 of Discovery, Mirror-Gergiou has been for quite some time in the Prime Universe. It would make total sense for her to refer to "her" universe as the mirror universe (basically using the same term that others are also using in-universe) and the prime universe as the "prime" one.
Update:
This is confirmed in Season 3, Episode 9 ("Terra Firma, Part 1") of Discovery, where Mirror-Georgiou clarifies:
"Where I'm from, we were prime, and you were the mirror."