I was reminded of this while researching Anime where genetically modified girls fight aliens/sea monsters. It was a webcomic that starred a buxom girl without arms (but with robotic floating waldos) who acted as something like a corporate-sponsored superheroine, fighting off creatures that came in by the sea. As the comic progressed, it was revealed first that the heroine's lack of arms was the result of her father trying to give her powers (basically, through some combination of chemicals and radiation, she wound up with the birth defect on non-developed limbs) and that the "monsters" are actually benign, carrying cargo for other companies, with her father's company seizing what they were carrying.
I remember there being sort of a timeskip, then she was kind of operating on her own, eventually befriending a girl with some sort of eldritch transformation resulting in eyes and mouths forming all over her body. I want to say there was some sort of romantic subplot going on there. And I think, not long after that, the webcomic was discontinued and then the creator took the site down. The artwork was pretty good, cartoony but well-drawn. A lot of lightly or spandex clad women with large breasts, as one often sees in such comics, occasional upper-body nudity. I think the creator had another webcomic strip they were better known for which was more adult.
And... in the process of pulling more details, I think I've found the answer.