The prohibition on the creation of Thinking Machines in the background of the Dune universe is well understood. However from those titles that I have read, the prime reason for this seems to be writen as to avoid the risk of creating a new machine tyranny; if it is as well understood as that. It's highly dogmatic at this point and maybe there is no such linear chain of reasoning in most people's minds. It seems at least as likely if not more so that the bigger risk would be of finding a remnant of the old Thinking Machines that is accidentally (or possibly selfishly and deliberately) reactivated. This would likely come pre-loaded with malicious sentience without having to develop it by accident. It's somewhat common-sense that an advanced computer not possessed of its own malice could be co-opted by one that is and used for evil, but this doesn't seem to be identified as a prime risk in the canon.
Do any titles in the Dune universe mention this, as a hypothetical or actual risk encountered in the main storyline?