I remember watching a series (or maybe a movie) about young adults or teenagers traveling away from Earth to try and find another planet to colonize after Earth has either been destroyed or infected with a virus. It's from either the 90s or early 2000s. The majority of the series is on their ship I think. It's definitely not Earth Star Voyager. I think it might have been a Disney series but I'm not sure.
A virus breaks out and leaves the humans residing on Earth doomed. However, in a desperate attempt before the end, all humanity's resources are dedicated to a crash program to produce a deep space ark, capable of seeding humanity on a new world. The ship is crewed by six clones; teenage versions of people who achieved great works during the ark project and equipped with the memories of their donors. Prior to its arrival, however, the crew is awoken prematurely to face a threat to the ship, before their memories are complete. They must come to terms with the workings of the ship, the dangers faced by their ship, the realization that they are clones, and their ultimate destiny to save their race.
In the mid-late 90's the Sci-Fi channel produced a show they called Mission Genesis (based on a book series called Deepwater Blue; the same show was called Deepwater Black on YTV), it revolved around teenage human clones flying a spaceship to find a new homeworld after Earth's population was wiped out from some sort of plague/biological weapon (I'm not sure which).