I don't remember exactly when I read this, but it was probably at least in college, and before I met my wife, which places it somewhere between 2000-2010. The protagonist is a caucasian adult male who, at the start of the comic book, has inherited a property. I don't remember if it was through a relative dying, or if he gained it as part of his job, because part of me wants to cast him as a religious person of some sort, and this was a church he was supposed to be caretaker for (sexton?). Shortly after settling in, he learns that the place is a sanctuary for a variety of monsters, although the details of them escape me. The only character I remember distinctly was some sort of a water monster, female, more overall fishlike than the typical mermaid, and I think with a normal bipedal build, with two arms and two legs. The two of them have a romantic relationship that was building up over the course of the book, although I don't think it had actually culminated at the time I stopped reading, possibly due to their differences of species. Monsters are not something which is common knowledge, and I think one of the central bits of the plot is that the main character has to protect the monsters from the townsfolk by keeping their existence secret, and providing for them, to avoid an angry pitchfork and torches mob situation. I want to say that the monsters included a vampire and a mummy, but again, my memories are very fuzzy.
As I recall it, the primary artwork was black-and-white, done in a mildly cartoonish style, not realistic but also not exaggerated. I think the covers were in color, which showed that the female monster love interest was blue. I think that she had fleshy growths coming off of her head, although I don't recall if they were fin-like ears or protrusions.