I do not have any official word from people who have adapted the first book, but as per my comment, A Wrinkle in Time is a weird book, often stated to be "unfilmable" and the sequels get weirder in some ways. A Wind in the Door starts right after the events of the first book with a new set of extradimensional teachers and a new cosmic threat that involves both stars being snuffed out and making Charles sick.
Instead of flinging themselves across the universe, Meg, Calvin, Progo, and Principal Jenkins (Meg’s nemesis from Wrinkle, who plays an important role in this story) save Charles Wallace from within by shrinking down and doing battle on a level that’s both cellular and metaphysical. There’s a lot of psychic speaking without words (“kything”) and celestial singing—as well as a very charismatic but non-verbal snake named Louise. All told, and even with blessedly less Charles Wallace this time around, this very interior story would be hugely challenging to adapt.
A Swiftly Tilting Planet has a massive time jump and involves time travel to try to ensure a South American dictator doesn't incite nuclear warfare by manipulating his ancestors, with the help of a magical unicorn. Many Waters brings in Sandy and Dennys and is a coming-of-age story involving Noah's Ark. The stories don't really follow each other and would likely sell to different crowds.
And probably more salient, the 2018 adaptation lost a lot of money and it looks like it's not just a matter of Hollywood Accounting.
A Wrinkle in Time grossed $100.5 million in the U.S. and Canada, and $32.2 million in other territories, for a worldwide total of $132.7 million. A combined $250 million was spent on production and advertisement. Following Disney's Q2 earnings report in May 2018, Yahoo! Finance deduced the film would lose the studio $86–186 million, and in April 2019, Deadline Hollywood calculated the film lost $130.6 million, when factoring together all expenses and revenues.
I don't have any information on what the return or liability on the 2003 adaptation was, but it was not well-received by critics:
As Diane Ortiz from The University Wire described it, the novel's first film adaptation was a "dud", emphasizing its lack of substantial acting and special effects.[6] In her same article, Eberson acknowledged a similar inadequacy in the special effects and explained how they did not meet the hopes of the creators nor the viewers. Nick Mangione, from Geek.com, suggested that many of the problems associated with the film relate to the creator's decision to dumb-down the concepts from the novel.[7] Mangione pointed out that in her novel, L'Engle trusted her audience and knew they would be able to understand the complex thoughts of the characters.[7] He believes that the film version shows no trust in the audience and spends the entire time simplifying everything and neglecting any of the more complex ideas. Mangione further stated, "It's almost impressive how they managed to take every major location and plot beat from the novel and get absolutely none of it right."
Madeleine L'Engle didn't like it either
NEWSWEEK: So you've seen the movie?
Madeleine L'Engle: I've glimpsed it.
And did it meet expectations?
Oh, yes. I expected it to be bad, and it is.