Sight of Proteus., and review.
By Charles Sheffield.
A three novel series. Part two is Proteus Unbound, part three is Proteus in the Underworld. The book series involves a minor amount of space travel towards the end. Parts appeared in various: Amazing, Galaxy.
Danny Flynn, Danny Flynn.com commercial site, 2017, fair usage.
Alternative cover-art:
Original novelisation art, copyright unknown, via review website 2022. Fair usage.
The main protagonist, a man by the name of Behrooz Wolf is a Form-Change expert and an investigator for the Office of Form-Change.
Complicating matters greatly is the emergence of Form Change, which
through simple biofeedback and other measures allows people to control
their body from its appearance (and gender) to subtle elements of
health itself. While experimenting with Form Change is fairly
dangerous (and some of the alternate forms have life-span multipliers
of .2) the average human can expect to live about a century, perhaps
as long as 120 years; increased lifespans only add to the population
problem.
The description then goes on to the point of discovery of the "alien" with odd DNA.:
When an over-eager student decides (fairly illegally) to practice
chromosome identification on a sample from the organ banks, he
discovers that the donor appears in no records, something that should
not be possible in this highly regulated world. Bey and John
investigate and despite the efforts of the prime suspect, another one
of this world’s well-connected masters, uncover a vast and old
conspiracy involving daring, often lethal and definitely illegal
experiments in Form Change.
The third novel, two of the characters have transformed into the alien form (with a society shattering life ratio of 3.5), and communicate at one point by data-link using their chests, modulating the colours and shapes of the light they are able to generate on their chests down to the pixel, communicating vast amounts in a short time. They call this "burst mode".
The "Huge brain in spaceship" part was Pearl, a converted hollow asteroid containing the ever-transforming female occupant, sent on an interstellar journey of exploration. She's older than she looks.